Novel mechanism of Interferon Suppression in Sandfly

SFSV NSs disrupts Interferon Induction

Our collaborators Jenny W├╝rth and Friedemann Weber identified a yet undescribed mechanism how Non-structural protein small (NSs) of Sandfly fever Sicilian phlebovirus perturbes type-I interferon induction: NSs directly associates to the DNA binding domain of the transcription factor IRF3 and thereby prevents induction of type-I interferon genes. Now published in Journal of Virology – Congratulations to Jenny!