About

Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.

Molecular Biology of Innate Immunity and Virus Infections
Virus proteins interact with the host cell receptors on the membrane and signalling proteins in the cytoplasm.

Headlines

New role of ZC3HAV1/ZAP in protection against HCMV
New role of ZC3HAV1/ZAP in protection against HCMV

The Brinkmann Lab employs a multi-omic approach to identify novel antiviral roles of ZAP in decelerating HCMV infections. We bring in the proteomic component.

New cGAS receptors and signalling identified in flies
New cGAS receptors and signalling identified in flies

We helped our collaborators from the Hartmann and Imler labs find two cGAS-like receptors that regulate antiviral immunity in flies!

ISG20, a host nuclease that degrades HBV’s cccDNA
ISG20, a host nuclease that degrades HBV’s cccDNA

Our collaboration with the Protzer Lab helps identify a new anti-HBV host factor, ISG20!

Our multi-omics analysis of SARS-COV-2 and SARS-CoV – in Nature!
Our multi-omics analysis of SARS-COV-2 and SARS-CoV – in Nature!

Scientific community can use these deep and comprehensive data to understand COVID-19 molecular mechanisms.

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