Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.
The Brinkmann Lab employs a multi-omic approach to identify novel antiviral roles of ZAP in decelerating HCMV infections. We bring in the proteomic component.
We helped our collaborators from the Hartmann and Imler labs find two cGAS-like receptors that regulate antiviral immunity in flies!
Our collaboration with the Protzer Lab helps identify a new anti-HBV host factor, ISG20!
Scientific community can use these deep and comprehensive data to understand COVID-19 molecular mechanisms.