Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.

Molecular Biology of Innate Immunity and Virus Infections
Virus proteins interact with the host cell receptors on the membrane and signalling proteins in the cytoplasm.


Non-redundant function of the alternative cap complex in antiviral immunity – published in PLOS Pathogens

Congratulations to Anna and Valter for publishing a function role of the alternative CBC!
The alternative cap binding complex consisting of NCBP1 and -3 exports mRNA but is redundant under physiological conditions. However, virus infection or challenge with innate immune stimuli revealed a critical function of the alternative CBC in modulation of the innate immune system. This was particularly evident in NCBP3 deficient mice that showed increased susceptibility to influenza A virus infection.

Antiviral Network of Proteins published in Nature Immunology

Philipp’s work on Interferon Stimulated Genes uncovered many unknown functions of the innate immune system

Andreas gets ERC Consolidator Grant!

Fantastic achievement that strengthens our positions at the front line of research

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