Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.

Molecular Biology of Innate Immunity and Virus Infections
Virus proteins interact with the host cell receptors on the membrane and signalling proteins in the cytoplasm.


Our review on screening strategies is published

Check out our new review „System-Based Approaches to Delineate the Antiviral Innate Immune Landscape“, recently published in Viruses.

Now available: SARS-CoV-2 testing platforms

Medium throughput functional screens and single cell genomics

New Paper on cellular effects of persistent expression of viral nucleic acids

Congratulations to Christian and Hendrik Welsch (Marco Binder lab). Their work on persistent stimulation of cells got accepted in Viruses.

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