Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.
New opportunities in cell death research!
Our collaborators from Bonn revealed the importance of host methyltransferase MTr1 for influenza and identified a novel anti-influenza compound - now published in Science!
Joining forces with our Danish friends at the Center for Immunology of Viral infections (CiViA)!
New publication from our lab in EMBO Reports! We discovered new host factors mediating SARS-CoV-2 entry and pathogenesis: ADAM17 and ADAM10.