Publications

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A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

P. Hubel, C. Urban, V. Bergant, W.M. Schneider, B. Knauer, A. Stukalov, P. Scaturro, A. Mann, L. Brunotte, H.H. Hoffmann, J.W. Schoggins, M. Schwemmle, M. Mann, C.M. Rice, A. Pichlmair

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (Journal Article)

Nat. Immunol., 2019, ISSN: 1529-2916.

(Abstract | Links | BibTeX)

An orthogonal proteomic survey uncovers novel Zika virus host factors

P. Scaturro, A. Stukalov, D.A. Haas, M. Cortese, K. Draganova, A. Płaszczyca, R. Bartenschlager, M. Götz, A. Pichlmair

An orthogonal proteomic survey uncovers novel Zika virus host factors (Journal Article)

Nature, 2018, ISSN: 1476-4687.

(Abstract | Links | BibTeX)

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

C. Holze, C. Michaudel, C. Mackowiak, D.A. Haas, C. Benda, P. Hubel, F.L. Pennemann, D. Schnepf, J. Wettmarshausen, M. Braun, D.W. Leung, G.K. Amarasinghe, F. Perocchi, P. Staeheli, B. Ryffel, A. Pichlmair

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway (Journal Article)

Nat. Immunol., 19 (2), pp. 130-140, 2017.

(Abstract | Links | BibTeX)

2019

P. Scaturro, A.L. Kastner, A. Pichlmair

Chasing Intracellular Zika Virus Using Proteomics (Journal Article)

Viruses, 11 (9), pp. 878, 2019.

(Abstract | Links | BibTeX)

A. Płaszczyca, P. Scaturro, C.J. Neufeldt, M. Cortese, B. Cerikan, S. Ferla, A. Brancale, A. Pichlmair, R. Bartenschlager

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle. (Journal Article)

PLoS Pathogens, 15 , pp. e1007736, 2019, ISSN: 1553-7374.

(Abstract | Links | BibTeX)

P. Hubel, C. Urban, V. Bergant, W.M. Schneider, B. Knauer, A. Stukalov, P. Scaturro, A. Mann, L. Brunotte, H.H. Hoffmann, J.W. Schoggins, M. Schwemmle, M. Mann, C.M. Rice, A. Pichlmair

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (Journal Article)

Nat. Immunol., 2019, ISSN: 1529-2916.

(Abstract | Links | BibTeX)

2018

P. Scaturro, A. Stukalov, D.A. Haas, M. Cortese, K. Draganova, A. Płaszczyca, R. Bartenschlager, M. Götz, A. Pichlmair

An orthogonal proteomic survey uncovers novel Zika virus host factors (Journal Article)

Nature, 2018, ISSN: 1476-4687.

(Abstract | Links | BibTeX)

P. Scaturro, A. Pichlmair

Oxeiptosis — a cell death pathway to mitigate damage caused by radicals (Journal Article)

Cell Death Diff., 25 (7), pp. 1191-1193, 2018.

(Links | BibTeX)

D.A. Haas, A. Meiler, K. Geiger, C. Vogt, E. Preuss, G. Kochs, A. Pichlmair

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity (Journal Article)

PLOS Pathogens, 14 (4), pp. e1006980, 2018, ISSN: 1553-7374.

(Abstract | Links | BibTeX)

2017

C. Holze, C. Michaudel, C. Mackowiak, D.A. Haas, C. Benda, P. Hubel, F.L. Pennemann, D. Schnepf, J. Wettmarshausen, M. Braun, D.W. Leung, G.K. Amarasinghe, F. Perocchi, P. Staeheli, B. Ryffel, A. Pichlmair

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway (Journal Article)

Nat. Immunol., 19 (2), pp. 130-140, 2017.

(Abstract | Links | BibTeX)

K. Vonderstein, E. Nilsson, P. Hubel, L. Nygård Skalman, A. Upadhyay, J. Pasto, A. Pichlmair, R. Lundmark, A.K. Överby

Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles. (Journal Article)

J Virol, 92 (1), pp. e01751-17, 2017, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

A. Gebhardt, B. Laudenbach, A. Pichlmair

Discrimination of Self and Non-Self Ribonucleic Acids (Journal Article)

J Interferon Cytokine Res., 37 (5), pp. 184-197, 2017.

(Abstract | Links | BibTeX)

N. Goonawardane, A. Gebhardt, C. Bartlett, A. Pichlmair, M. Harris

Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. (Journal Article)

J Virol, 91 , 2017, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

G. Brady, D.A. Haas, P.J. Farrell, A. Pichlmair, A.G. Bowie

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation. (Journal Article)

J Virol, 91 , 2017, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

Y.M. Abbas, B. Laudenbach, S. Martínez-Montero, R. Cencic, M. Habjan, A. Pichlmair, M.J. Damha, J. Pelletier, B. Nagar

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. (Journal Article)

Proc Natl Acad Sci U S A, 114 , pp. E2106–E2115, 2017, ISSN: 1091-6490.

(Abstract | Links | BibTeX)

Joschka Willemsen, Oliver Wicht, Julia C Wolanski, Nina Baur, Sandra Bastian, Darya A Haas, Petr Matula, Bettina Knapp, Laurène Meyniel-Schicklin, Chen Wang, Ralf Bartenschlager, Volker Lohmann, Karl Rohr, Holger Erfle, Lars Kaderali, Joseph Marcotrigiano, Andreas Pichlmair, Marco Binder

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. (Journal Article)

Mol Cell, 65 , pp. 403–415.e8, 2017, ISSN: 1097-4164.

(Abstract | Links | BibTeX)

2016

A. Mazouzi, A. Stukalov, A.C. Müller, D. Chen, M. Wiedner, J. Prochazkova, S. Chiang, M. Schuster, F.P. Breitwieser, A. Pichlmair, S.F. El-Khamisy, C. Bock, R. Kralovics, J. Colinge, K.L. Bennett, J.I. Loizou

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. (Journal Article)

Cell reports, 15 , pp. 893–908, 2016, ISSN: 2211-1247.

(Abstract | Links | BibTeX)

2015

A. Stukalov, A. Pichlmair

Gambling with Flu: "All in" to Maximize Reward (Journal Article)

Cell host microbe, 18 (6), pp. 643–645, 2015, ISSN: 1934-6069.

(Abstract | Links | BibTeX)

A. Gebhardt, M. Habjan, C. Benda, A. Meiler, D.A. Haas, M.Y. Hein, A. Mann, M. Mann, B. Habermann, A. Pichlmair

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3 (Journal Article)

Nat commun, 6 , pp. 8192, 2015, ISSN: 2041-1723.

(Abstract | Links | BibTeX)

Leonhard X Heinz, Christoph L Baumann, Marielle S Köberlin, Berend Snijder, Riem Gawish, Guanghou Shui, Omar Sharif, Irene M Aspalter, André C Müller, Richard K Kandasamy, Florian P Breitwieser, Andreas Pichlmair, Manuela Bruckner, Manuele Rebsamen, Stephan Blüml, Thomas Karonitsch, Astrid Fauster, Jacques Colinge, Keiryn L Bennett, Sylvia Knapp, Markus R Wenk, Giulio Superti-Furga

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. (Journal Article)

Cell reports, 11 , pp. 1919–1928, 2015, ISSN: 2211-1247.

(Abstract | Links | BibTeX)

Gareth Brady, Darya A Haas, Paul J Farrell, Andreas Pichlmair, Andrew G Bowie

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation. (Journal Article)

J Virol, 89 , pp. 8406–8415, 2015, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

Matthias Habjan, Andreas Pichlmair

Cytoplasmic sensing of viral nucleic acids. (Journal Article)

Current opinion in virology, 11 , pp. 31–37, 2015, ISSN: 1879-6265.

(Abstract | Links | BibTeX)

2014

Carol-Ann Eberle, Margarita Zayas, Alexey Stukalov, Andreas Pichlmair, Gualtiero Alvisi, André C Müller, Keiryn L Bennett, Ralf Bartenschlager, Giulio Superti-Furga

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production. (Journal Article)

Virology, 462-463 , pp. 34–41, 2014, ISSN: 1096-0341.

(Abstract | Links | BibTeX)

Markus Kainulainen, Matthias Habjan, Philipp Hubel, Laura Busch, Simone Lau, Jacques Colinge, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. (Journal Article)

J Virol, 88 , pp. 3464–3473, 2014, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. (Journal Article)

Nat Med, 20 , pp. 47–53, 2014, ISSN: 1546-170X.

(Abstract | Links | BibTeX)

Arunkumar S Upadhyay, Kirstin Vonderstein, Andreas Pichlmair, Oliver Stehling, Keiryn L Bennett, Gerhard Dobler, Ju-Tao Guo, Giulio Superti-Furga, Roland Lill, Anna K Överby, Friedemann Weber

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. (Journal Article)

Cell Microbiol, 16 , pp. 834–848, 2014, ISSN: 1462-5822.

(Abstract | Links | BibTeX)

2013

Matthias Habjan, Philipp Hubel, Livia Lacerda, Christian Benda, Cathleen Holze, Christian H Eberl, Angelika Mann, Eveline Kindler, Cristina Gil-Cruz, John Ziebuhr, Volker Thiel, Andreas Pichlmair

Sequestration by IFIT1 impairs translation of 2Ó-unmethylated capped RNA. (Journal Article)

PLoS Pathog, 9 , pp. e1003663, 2013, ISSN: 1553-7374.

(Abstract | Links | BibTeX)

Yazan M Abbas, Andreas Pichlmair, Maria W Górna, Giulio Superti-Furga, Bhushan Nagar

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. (Journal Article)

Nature, 494 , pp. 60–64, 2013, ISSN: 1476-4687.

(Abstract | Links | BibTeX)

2012

Andreas Pichlmair, Kumaran Kandasamy, Gualtiero Alvisi, Orla Mulhern, Roberto Sacco, Matthias Habjan, Marco Binder, Adrijana Stefanovic, Carol-Ann Eberle, Adriana Goncalves, Tilmann Bürckstümmer, André C Müller, Astrid Fauster, Cathleen Holze, Kristina Lindsten, Stephen Goodbourn, Georg Kochs, Friedemann Weber, Ralf Bartenschlager, Andrew G Bowie, Keiryn L Bennett, Jacques Colinge, Giulio Superti-Furga

Viral immune modulators perturb the human molecular network by common and unique strategies. (Journal Article)

Nature, 487 , pp. 486–490, 2012, ISSN: 1476-4687.

(Abstract | Links | BibTeX)

2011

Andreas Pichlmair, Caroline Lassnig, Carol-Ann Eberle, Maria W Górna, Christoph L Baumann, Thomas R Burkard, Tilmann Bürckstümmer, Adrijana Stefanovic, Sigurd Krieger, Keiryn L Bennett, Thomas Rülicke, Friedemann Weber, Jacques Colinge, Mathias Müller, Giulio Superti-Furga

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (Journal Article)

Nat Immunol, 12 , pp. 624–630, 2011, ISSN: 1529-2916.

(Abstract | Links | BibTeX)

2010

Christoph L Baumann, Irene M Aspalter, Omar Sharif, Andreas Pichlmair, Stephan Blüml, Florian Grebien, Manuela Bruckner, Pawel Pasierbek, Karin Aumayr, Melanie Planyavsky, Keiryn L Bennett, Jacques Colinge, Sylvia Knapp, Giulio Superti-Furga

CD14 is a coreceptor of Toll-like receptors 7 and 9. (Journal Article)

The Journal of experimental medicine, 207 , pp. 2689–2701, 2010, ISSN: 1540-9538.

(Abstract | Links | BibTeX)

Andreas Pichlmair, Matthias Habjan, Hermann Unger, Friedemann Weber

Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus. (Journal Article)

Vector borne and zoonotic diseases (Larchmont, N.Y.), 10 , pp. 701–703, 2010, ISSN: 1557-7759.

(Abstract | Links | BibTeX)

Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J Kaufman, Caetano Reis e Sousa

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. (Journal Article)

Cell Host Microbe, 7 , pp. 354–361, 2010, ISSN: 1934-6069.

(Abstract | Links | BibTeX)

Jan Rehwinkel, Choon Ping Tan, Delphine Goubau, Oliver Schulz, Andreas Pichlmair, Katja Bier, Nicole Robb, Frank Vreede, Wendy Barclay, Ervin Fodor, Caetano Reis e Sousa

RIG-I detects viral genomic RNA during negative-strand RNA virus infection. (Journal Article)

Cell, 140 , pp. 397–408, 2010, ISSN: 1097-4172.

(Abstract | Links | BibTeX)

2009

Andreas Pichlmair, Oliver Schulz, Choon-Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis e Sousa

Activation of MDA5 requires higher-order RNA structures generated during virus infection. (Journal Article)

J Virol, 83 , pp. 10761–10769, 2009, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

M. Habjan, A. Pichlmair, R.M. Elliott, A.K. Överby, T. Glatter, M. Gstaiger, G. Superti-Furga, H. Unger, F. Weber

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. (Journal Article)

J Virol, 83 , pp. 4365–4375, 2009, ISSN: 1098-5514.

(Abstract | Links | BibTeX)

2008

Matthias Habjan, Ida Andersson, Jonas Klingström, Michael Schümann, Arnold Martin, Petra Zimmermann, Valentina Wagner, Andreas Pichlmair, Urs Schneider, Elke Mühlberger, Ali Mirazimi, Friedemann Weber

Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. (Journal Article)

PLoS One, 3 , pp. e2032, 2008, ISSN: 1932-6203.

(Abstract | Links | BibTeX)

2007

Andreas Pichlmair, Caetano Reis e Sousa

Innate recognition of viruses. (Journal Article)

Immunity, 27 , pp. 370–383, 2007, ISSN: 1074-7613.

(Abstract | Links | BibTeX)

Andreas Pichlmair, Sandra S Diebold, Stephen Gschmeissner, Yasuhiro Takeuchi, Yasuhiro Ikeda, Mary K Collins, Caetano Reis e Sousa

Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. (Journal Article)

J Virol, 81 , pp. 539–547, 2007, ISSN: 0022-538X.

(Abstract | Links | BibTeX)

2006

Andreas Pichlmair, Oliver Schulz, Choon Ping Tan, Tanja I Näslund, Peter Liljeström, Friedemann Weber, Caetano Reis e Sousa

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. (Journal Article)

Science (New York, N.Y.), 314 , pp. 997–1001, 2006, ISSN: 1095-9203.

(Abstract | Links | BibTeX)

2005

Martin Spiegel, Andreas Pichlmair, Luis Martínez-Sobrido, Jerome Cros, Adolfo García-Sastre, Otto Haller, Friedemann Weber

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. (Journal Article)

J Virol, 79 , pp. 2079–2086, 2005, ISSN: 0022-538X.

(Abstract | Links | BibTeX)

2004

Andreas Pichlmair, Johanna Buse, Stephanie Jennings, Otto Haller, Georg Kochs, Peter Staeheli

Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice. (Journal Article)

J Virol, 78 , pp. 11422–11424, 2004, ISSN: 0022-538X.

(Abstract | Links | BibTeX)

Andreas Pichlmair, Matthias Pollak, Andreas Bergthaler

[The first answer to viral infections: type I interferon]. (Journal Article)

Berl Munch Tierarztl Wochenschr, 117 , pp. 252–265, 2004, ISSN: 0005-9366.

(Abstract | BibTeX)

Martin Spiegel, Andreas Pichlmair, Elke Mühlberger, Otto Haller, Friedemann Weber

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein. (Journal Article)

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 30 , pp. 211–213, 2004, ISSN: 1386-6532.

(Abstract | Links | BibTeX)

2003

H Weissenböck, Z Hubálek, J Halouzka, A Pichlmair, A Maderner, K Fragner, J Kolodziejek, G Loupal, S Kölbl, N Nowotny

Screening for West Nile virus infections of susceptible animal species in Austria. (Journal Article)

Epidemiol Infect, 131 , pp. 1023–1027, 2003, ISSN: 0950-2688.

(Abstract | BibTeX)