Publications

Featured

An orthogonal proteomic survey uncovers novel Zika virus host factorsP. Scaturro, A. Stukalov, D.A. Haas, M. Cortese, K. Draganova, A. Płaszczyca, R. Bartenschlager, M. Götz, A. Pichlmair An orthogonal proteomic survey uncovers novel Zika virus host factors Nature, 2018, ISSN: 1476-4687. Abstract | Links | BibTeX
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathwayC. Holze, C. Michaudel, C. Mackowiak, D.A. Haas, C. Benda, P. Hubel, F.L. Pennemann, D. Schnepf, J. Wettmarshausen, M. Braun, D.W. Leung, G.K. Amarasinghe, F. Perocchi, P. Staeheli, B. Ryffel, A. Pichlmair Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway Nat. Immunol., 19 (2), pp. 130-140, 2017. Abstract | Links | BibTeX
mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3A. Gebhardt, M. Habjan, C. Benda, A. Meiler, D.A. Haas, M.Y. Hein, A. Mann, M. Mann, B. Habermann, A. Pichlmair mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3 Nat commun, 6 , pp. 8192, 2015, ISSN: 2041-1723. Abstract | Links | BibTeX

2018

P. Scaturro, A. Stukalov, D.A. Haas, M. Cortese, K. Draganova, A. Płaszczyca, R. Bartenschlager, M. Götz, A. Pichlmair An orthogonal proteomic survey uncovers novel Zika virus host factors Nature, 2018, ISSN: 1476-4687. Abstract | Links | BibTeX
P. Scaturro, A. Pichlmair Oxeiptosis — a cell death pathway to mitigate damage caused by radicals Cell Death Diff., 25 (7), pp. 1191-1193, 2018. Links | BibTeX
D.A. Haas, A. Meiler, K. Geiger, C. Vogt, E. Preuss, G. Kochs, A. Pichlmair Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity PLOS Pathogens, 14 (4), pp. e1006980, 2018, ISSN: 1553-7374. Abstract | Links | BibTeX

2017

C. Holze, C. Michaudel, C. Mackowiak, D.A. Haas, C. Benda, P. Hubel, F.L. Pennemann, D. Schnepf, J. Wettmarshausen, M. Braun, D.W. Leung, G.K. Amarasinghe, F. Perocchi, P. Staeheli, B. Ryffel, A. Pichlmair Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway Nat. Immunol., 19 (2), pp. 130-140, 2017. Abstract | Links | BibTeX
K. Vonderstein, E. Nilsson, P. Hubel, L. Nygård Skalman, A. Upadhyay, J. Pasto, A. Pichlmair, R. Lundmark, A.K. Överby Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles. J Virol, 92 (1), pp. e01751-17, 2017, ISSN: 1098-5514. Abstract | Links | BibTeX
A. Gebhardt, B. Laudenbach, A. Pichlmair Discrimination of Self and Non-Self Ribonucleic Acids J Interferon Cytokine Res., 37 (5), pp. 184-197, 2017. Abstract | Links | BibTeX
N. Goonawardane, A. Gebhardt, C. Bartlett, A. Pichlmair, M. Harris Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. J Virol, 91 , 2017, ISSN: 1098-5514. Abstract | Links | BibTeX
G. Brady, D.A. Haas, P.J. Farrell, A. Pichlmair, A.G. Bowie Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation. J Virol, 91 , 2017, ISSN: 1098-5514. Abstract | Links | BibTeX
Y.M. Abbas, B. Laudenbach, S. Martínez-Montero, R. Cencic, M. Habjan, A. Pichlmair, M.J. Damha, J. Pelletier, B. Nagar Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc Natl Acad Sci U S A, 114 , pp. E2106–E2115, 2017, ISSN: 1091-6490. Abstract | Links | BibTeX
Joschka Willemsen, Oliver Wicht, Julia C Wolanski, Nina Baur, Sandra Bastian, Darya A Haas, Petr Matula, Bettina Knapp, Laurène Meyniel-Schicklin, Chen Wang, Ralf Bartenschlager, Volker Lohmann, Karl Rohr, Holger Erfle, Lars Kaderali, Joseph Marcotrigiano, Andreas Pichlmair, Marco Binder Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell, 65 , pp. 403–415.e8, 2017, ISSN: 1097-4164. Abstract | Links | BibTeX

2016

A. Mazouzi, A. Stukalov, A.C. Müller, D. Chen, M. Wiedner, J. Prochazkova, S. Chiang, M. Schuster, F.P. Breitwieser, A. Pichlmair, S.F. El-Khamisy, C. Bock, R. Kralovics, J. Colinge, K.L. Bennett, J.I. Loizou A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell reports, 15 , pp. 893–908, 2016, ISSN: 2211-1247. Abstract | Links | BibTeX

2015

A. Stukalov, A. Pichlmair Gambling with Flu: "All in" to Maximize Reward Cell host microbe, 18 (6), pp. 643–645, 2015, ISSN: 1934-6069. Abstract | Links | BibTeX
A. Gebhardt, M. Habjan, C. Benda, A. Meiler, D.A. Haas, M.Y. Hein, A. Mann, M. Mann, B. Habermann, A. Pichlmair mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3 Nat commun, 6 , pp. 8192, 2015, ISSN: 2041-1723. Abstract | Links | BibTeX
Leonhard X Heinz, Christoph L Baumann, Marielle S Köberlin, Berend Snijder, Riem Gawish, Guanghou Shui, Omar Sharif, Irene M Aspalter, André C Müller, Richard K Kandasamy, Florian P Breitwieser, Andreas Pichlmair, Manuela Bruckner, Manuele Rebsamen, Stephan Blüml, Thomas Karonitsch, Astrid Fauster, Jacques Colinge, Keiryn L Bennett, Sylvia Knapp, Markus R Wenk, Giulio Superti-Furga The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell reports, 11 , pp. 1919–1928, 2015, ISSN: 2211-1247. Abstract | Links | BibTeX
Gareth Brady, Darya A Haas, Paul J Farrell, Andreas Pichlmair, Andrew G Bowie Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation. J Virol, 89 , pp. 8406–8415, 2015, ISSN: 1098-5514. Abstract | Links | BibTeX
Matthias Habjan, Andreas Pichlmair Cytoplasmic sensing of viral nucleic acids. Current opinion in virology, 11 , pp. 31–37, 2015, ISSN: 1879-6265. Abstract | Links | BibTeX

2014

Carol-Ann Eberle, Margarita Zayas, Alexey Stukalov, Andreas Pichlmair, Gualtiero Alvisi, André C Müller, Keiryn L Bennett, Ralf Bartenschlager, Giulio Superti-Furga The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production. Virology, 462-463 , pp. 34–41, 2014, ISSN: 1096-0341. Abstract | Links | BibTeX
Markus Kainulainen, Matthias Habjan, Philipp Hubel, Laura Busch, Simone Lau, Jacques Colinge, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol, 88 , pp. 3464–3473, 2014, ISSN: 1098-5514. Abstract | Links | BibTeX
Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med, 20 , pp. 47–53, 2014, ISSN: 1546-170X. Abstract | Links | BibTeX
Arunkumar S Upadhyay, Kirstin Vonderstein, Andreas Pichlmair, Oliver Stehling, Keiryn L Bennett, Gerhard Dobler, Ju-Tao Guo, Giulio Superti-Furga, Roland Lill, Anna K Överby, Friedemann Weber Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol, 16 , pp. 834–848, 2014, ISSN: 1462-5822. Abstract | Links | BibTeX

2013

Matthias Habjan, Philipp Hubel, Livia Lacerda, Christian Benda, Cathleen Holze, Christian H Eberl, Angelika Mann, Eveline Kindler, Cristina Gil-Cruz, John Ziebuhr, Volker Thiel, Andreas Pichlmair Sequestration by IFIT1 impairs translation of 2Ó-unmethylated capped RNA. PLoS Pathog, 9 , pp. e1003663, 2013, ISSN: 1553-7374. Abstract | Links | BibTeX
Yazan M Abbas, Andreas Pichlmair, Maria W Górna, Giulio Superti-Furga, Bhushan Nagar Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494 , pp. 60–64, 2013, ISSN: 1476-4687. Abstract | Links | BibTeX

2012

Andreas Pichlmair, Kumaran Kandasamy, Gualtiero Alvisi, Orla Mulhern, Roberto Sacco, Matthias Habjan, Marco Binder, Adrijana Stefanovic, Carol-Ann Eberle, Adriana Goncalves, Tilmann Bürckstümmer, André C Müller, Astrid Fauster, Cathleen Holze, Kristina Lindsten, Stephen Goodbourn, Georg Kochs, Friedemann Weber, Ralf Bartenschlager, Andrew G Bowie, Keiryn L Bennett, Jacques Colinge, Giulio Superti-Furga Viral immune modulators perturb the human molecular network by common and unique strategies. Nature, 487 , pp. 486–490, 2012, ISSN: 1476-4687. Abstract | Links | BibTeX

2011

Andreas Pichlmair, Caroline Lassnig, Carol-Ann Eberle, Maria W Górna, Christoph L Baumann, Thomas R Burkard, Tilmann Bürckstümmer, Adrijana Stefanovic, Sigurd Krieger, Keiryn L Bennett, Thomas Rülicke, Friedemann Weber, Jacques Colinge, Mathias Müller, Giulio Superti-Furga IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol, 12 , pp. 624–630, 2011, ISSN: 1529-2916. Abstract | Links | BibTeX

2010

Christoph L Baumann, Irene M Aspalter, Omar Sharif, Andreas Pichlmair, Stephan Blüml, Florian Grebien, Manuela Bruckner, Pawel Pasierbek, Karin Aumayr, Melanie Planyavsky, Keiryn L Bennett, Jacques Colinge, Sylvia Knapp, Giulio Superti-Furga CD14 is a coreceptor of Toll-like receptors 7 and 9. The Journal of experimental medicine, 207 , pp. 2689–2701, 2010, ISSN: 1540-9538. Abstract | Links | BibTeX
Andreas Pichlmair, Matthias Habjan, Hermann Unger, Friedemann Weber Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus. Vector borne and zoonotic diseases (Larchmont, N.Y.), 10 , pp. 701–703, 2010, ISSN: 1557-7759. Abstract | Links | BibTeX
Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J Kaufman, Caetano Reis e Sousa Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe, 7 , pp. 354–361, 2010, ISSN: 1934-6069. Abstract | Links | BibTeX
Jan Rehwinkel, Choon Ping Tan, Delphine Goubau, Oliver Schulz, Andreas Pichlmair, Katja Bier, Nicole Robb, Frank Vreede, Wendy Barclay, Ervin Fodor, Caetano Reis e Sousa RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell, 140 , pp. 397–408, 2010, ISSN: 1097-4172. Abstract | Links | BibTeX

2009

Andreas Pichlmair, Oliver Schulz, Choon-Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis e Sousa Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol, 83 , pp. 10761–10769, 2009, ISSN: 1098-5514. Abstract | Links | BibTeX
M. Habjan, A. Pichlmair, R.M. Elliott, A.K. Överby, T. Glatter, M. Gstaiger, G. Superti-Furga, H. Unger, F. Weber NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol, 83 , pp. 4365–4375, 2009, ISSN: 1098-5514. Abstract | Links | BibTeX

2008

Matthias Habjan, Ida Andersson, Jonas Klingström, Michael Schümann, Arnold Martin, Petra Zimmermann, Valentina Wagner, Andreas Pichlmair, Urs Schneider, Elke Mühlberger, Ali Mirazimi, Friedemann Weber Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. PLoS One, 3 , pp. e2032, 2008, ISSN: 1932-6203. Abstract | Links | BibTeX

2007

Andreas Pichlmair, Caetano Reis e Sousa Innate recognition of viruses. Immunity, 27 , pp. 370–383, 2007, ISSN: 1074-7613. Abstract | Links | BibTeX
Andreas Pichlmair, Sandra S Diebold, Stephen Gschmeissner, Yasuhiro Takeuchi, Yasuhiro Ikeda, Mary K Collins, Caetano Reis e Sousa Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J Virol, 81 , pp. 539–547, 2007, ISSN: 0022-538X. Abstract | Links | BibTeX

2006

Andreas Pichlmair, Oliver Schulz, Choon Ping Tan, Tanja I Näslund, Peter Liljeström, Friedemann Weber, Caetano Reis e Sousa RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (New York, N.Y.), 314 , pp. 997–1001, 2006, ISSN: 1095-9203. Abstract | Links | BibTeX

2005

Martin Spiegel, Andreas Pichlmair, Luis Martínez-Sobrido, Jerome Cros, Adolfo García-Sastre, Otto Haller, Friedemann Weber Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. J Virol, 79 , pp. 2079–2086, 2005, ISSN: 0022-538X. Abstract | Links | BibTeX

2004

Andreas Pichlmair, Johanna Buse, Stephanie Jennings, Otto Haller, Georg Kochs, Peter Staeheli Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice. J Virol, 78 , pp. 11422–11424, 2004, ISSN: 0022-538X. Abstract | Links | BibTeX
Andreas Pichlmair, Matthias Pollak, Andreas Bergthaler [The first answer to viral infections: type I interferon]. Berl Munch Tierarztl Wochenschr, 117 , pp. 252–265, 2004, ISSN: 0005-9366. Abstract | BibTeX
Martin Spiegel, Andreas Pichlmair, Elke Mühlberger, Otto Haller, Friedemann Weber The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 30 , pp. 211–213, 2004, ISSN: 1386-6532. Abstract | Links | BibTeX

2003

H Weissenböck, Z Hubálek, J Halouzka, A Pichlmair, A Maderner, K Fragner, J Kolodziejek, G Loupal, S Kölbl, N Nowotny Screening for West Nile virus infections of susceptible animal species in Austria. Epidemiol Infect, 131 , pp. 1023–1027, 2003, ISSN: 0950-2688. Abstract | BibTeX