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Multilevel Proteomics Reveals Host Perturbations by SARS-CoV-2 and SARS-CoV

A. Stukalov, V. Girault, V. Grass, O. Karayel, V. Bergant, C. Urban, D.A. Haas, Y. Huang, L. Oubraham, A. Wang, M.S. Hamad, A. Piras, F.M. Hansen, M.C. Tanzer, I. Paron, L. Zinzula, T. Enghleitner, M. Reinecke, T.M. Lavacca, R. Ehmann, R. Wölfel, J. Jores, B. Kuster, U. Protzer, R. Rad, J. Ziebuhr, V. Thiel, P. Scaturro, M. Mann, A. Pichlmair

Multilevel Proteomics Reveals Host Perturbations by SARS-CoV-2 and SARS-CoV Journal Article

In: Nature, 2021, ISSN: 0028-0836.

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A Protein-interaction Network of Interferon-stimulated Genes Extends the Innate Immune System Landscape

P. Hubel, C. Urban, V. Bergant, W.M. Schneider, B. Knauer, A. Stukalov, P. Scaturro, A. Mann, L. Brunotte, H.H. Hoffmann, J.W. Schoggins, M. Schwemmle, M. Mann, C.M. Rice, A. Pichlmair

A Protein-interaction Network of Interferon-stimulated Genes Extends the Innate Immune System Landscape Journal Article

In: Nat. Immunol., 2019, ISSN: 1529-2916.

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An Orthogonal Proteomic Survey Uncovers Novel Zika Virus Host Factors

P. Scaturro, A. Stukalov, D.A. Haas, M. Cortese, K. Draganova, A. Płaszczyca, R. Bartenschlager, M. Götz, A. Pichlmair

An Orthogonal Proteomic Survey Uncovers Novel Zika Virus Host Factors Journal Article

In: Nature, 2018, ISSN: 1476-4687.

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Oxeiptosis, a ROS-induced Caspase-independent Apoptosis-like Cell-death Pathway

C. Holze, C. Michaudel, C. Mackowiak, D.A. Haas, C. Benda, P. Hubel, F.L. Pennemann, D. Schnepf, J. Wettmarshausen, M. Braun, D.W. Leung, G.K. Amarasinghe, F. Perocchi, P. Staeheli, B. Ryffel, A. Pichlmair

Oxeiptosis, a ROS-induced Caspase-independent Apoptosis-like Cell-death Pathway Journal Article

In: Nat. Immunol., vol. 19, no. 2, pp. 130-140, 2017.

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98 entries « 1 of 2 »

2025

Charlotte Rothfuß, Tobias Baumann, Sainitin Donakonda, Bettina Brauchle, Anetta Marcinek, Christian Urban, Julia Mergner, Anna-Marie Pedde, Anna Hirschberger, Christina Krupka, Anne-Sophie Neumann, Gerulf Hänel, Camilla Merten, Rupert Öllinger, Judith S Hecker, Tanja Bauer, Christian Rudolf Schmid, Katharina S Götze, Jennifer Altomonte, Veit L Bücklein, Roland Jacobs, Roland Rad, Corinna Dawid, Luca Simeoni, Burkhart Schraven, Andreas Pichlmair, Marion Subklewe, Percy Alexander Knolle, Jan P Böttcher, Bastian Höchst

Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells Journal Article

In: Blood, 2025, ISSN: 1528-0020.

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Wesley Freppel, Viviana Andrea Barragan Torres, Olus Uyar, Anaïs Anton, Zaynab Nouhi, Mathilde Broquière, Clément Mazeaud, Aïssatou Aïcha Sow, Alexanne Léveillé, Claudia Gilbert, Nicolas Tremblay, Jonathan Eintrez Owen, Cheyanne L Bemis, Xavier Laulhé, Alain Lamarre, Christopher J Neufeldt, Ian Gaël Rodrigue-Gervais, Andreas Pichlmair, Denis Girard, Pietro Scaturro, Laura Hulea, Laurent Chatel-Chaix

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis Journal Article

In: iScience, vol. 28, no. 1, pp. 111599, 2025, ISSN: 2589-0042.

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Chunkyu Ko, Cho-Chin Cheng, Daniele Mistretta, Shubhankar Ambike, Julia Sacherl, Stoyan Velkov, Bo-Hung Liao, Romina Bester, Merve Gültan, Olga Polezhaeva, Alexander Herrmann, Constanze A Jakwerth, Carsten B Schmidt-Weber, Joachim J Bugert, Roman Wölfel, Vincent Grass, Sandra Essbauer, Daniel Schnepf, Oliver T Keppler, Florian W R Vondran, Andreas Pichlmair, Carolin Mogler, Gregor Ebert, Ulrike Protzer

SARS-CoV-2 Productively Infects Human Hepatocytes and Induces Cell Death Journal Article

In: J Med Virol, vol. 97, no. 1, pp. e70156, 2025, ISSN: 1096-9071.

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2024

Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I Journal Article

In: EMBO J, 2024, ISSN: 1460-2075.

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Søren R Paludan, Thomas Pradeu, Andreas Pichlmair, K Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H Mogensen

Early host defense against virus infections Journal Article

In: Cell Rep, vol. 43, no. 12, pp. 115070, 2024, ISSN: 2211-1247.

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Christiane Guder, Soraya Heinrich, Vanadin Seifert-Klauss, Marion Kiechle, Lisa Bauer, Rupert Öllinger, Andreas Pichlmair, Marie-Nicole Theodoraki, Veena Ramesh, Ali Bashiri Dezfouli, Barbara Wollenberg, Alan Graham Pockley, Gabriele Multhoff

Extracellular Hsp70 and Circulating Endometriotic Cells as Novel Biomarkers for Endometriosis Journal Article

In: Int J Mol Sci, vol. 25, no. 21, 2024, ISSN: 1422-0067.

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Yiqi Huang, Christian Urban, Philipp Hubel, Alexey Stukalov, Andreas Pichlmair

Protein turnover regulation is critical for influenza A virus infection Journal Article

In: Cell Syst, vol. 15, no. 10, pp. 911–929.e8, 2024, ISSN: 2405-4720.

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Anna Macht, Yiqi Huang, Line S Reinert, Vincent Grass, Kristin Lohmer, Elke Tatjana Aristizabal Prada, Eveline Babel, Alexandra Semmler, Wen Zhang, Andrea Wegner, Eva Lichtenegger-Hartl, Sonja Haas, Günther Hasenpusch, Steffen Meyer, Søren R Paludan, Andreas Pichlmair, Carsten Rudolph, Thomas Langenickel

Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice Journal Article

In: EMBO Rep, vol. 25, no. 9, pp. 3777–3788, 2024, ISSN: 1469-3178.

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Mariya Al Hamrashdi, Carla Sanchez Perez, Darya A Haas, Jyoti Vishwakarma, Andreas Pichlmair, Andrew G Bowie, Gareth Brady

Molluscum contagiosum virus protein MC089 inhibits interferon regulatory factor 3 activation Journal Article

In: J Gen Virol, vol. 105, no. 8, 2024, ISSN: 1465-2099.

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Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I Schmidt, Michael Way, Roland Rad, Andrew G Bowie, Ulrike Protzer, Andreas Pichlmair

Multi-omics characterization of the monkeypox virus infection Journal Article

In: Nat Commun, vol. 15, no. 1, pp. 6778, 2024, ISSN: 2041-1723.

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Christoph Gruber, Lea Krautner, Valter Bergant, Vincent Grass, Zhe Ma, Lara Rheinemann, Ariane Krus, Friederike Reinhardt, Lyupka Mazneykova, Marianne Rocha-Hasler, Dong-Jiunn Jeffery Truong, Gil Gregor Westmeyer, Andreas Pichlmair, Gregor Ebert, Florian Giesert, Wolfgang Wurst

Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting Journal Article

In: Cell Discov, vol. 10, no. 1, pp. 42, 2024, ISSN: 2056-5968.

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Constanze A. Jakwerth, Vincent Grass, Anna Erb, Andreas Pichlmair, Georg Boonen, Veronika Butterweck, Carsten B. Schmidt-Weber

Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339) Journal Article

In: Biomedicine & Pharmacotherapy, vol. 170, 2024, ISSN: 0753-3322.

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2023

Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways Journal Article

In: Nat Commun, vol. 14, no. 1, 2023, ISSN: 2041-1723.

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Valter Bergant, Daniel Schnepf, Niklas de Andrade Krätzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus Journal Article

In: Nat Commun, vol. 14, no. 1, 2023, ISSN: 2041-1723.

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Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Søren Riis Paludan, Anne Krug, Roland Rad, Veit Hornung, Andreas Pichlmair

Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages Journal Article

In: The EMBO Journal, vol. 42, no. 23, 2023, ISSN: 1460-2075.

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Solène Denolly, Hongbo Guo, Miriam Martens, Anna Płaszczyca, Pietro Scaturro, Vibhu Prasad, Kessiri Kongmanas, Nuntaya Punyadee, Adisak Songjaeng, Dumrong Mairiang, Andreas Pichlmair, Panisadee Avirutnan, Ralf Bartenschlager

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin Journal Article

In: mBio, vol. 14, no. 5, 2023, ISSN: 2150-7511.

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Nora Schmidt, Sabina Ganskih, Yuanjie Wei, Alexander Gabel, Sebastian Zielinski, Hasmik Keshishian, Caleb A. Lareau, Liv Zimmermann, Jana Makroczyova, Cadence Pearce, Karsten Krey, Thomas Hennig, Sebastian Stegmaier, Lambert Moyon, Marc Horlacher, Simone Werner, Jens Aydin, Marco Olguin-Nava, Ramya Potabattula, Anuja Kibe, Lars Dölken, Redmond P. Smyth, Neva Caliskan, Annalisa Marsico, Christine Krempl, Jochen Bodem, Andreas Pichlmair, Steven A. Carr, Petr Chlanda, Florian Erhard, Mathias Munschauer

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9 Journal Article

In: Cell, vol. 186, no. 22, pp. 4834–4850.e23, 2023, ISSN: 0092-8674.

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Sandy S Burkart, Darius Schweinoch, Jamie Frankish, Carola Sparn, Sandra Wüst, Christian Urban, Marta Merlo, Vladimir G Magalhães, Antonio Piras, Andreas Pichlmair, Joschka Willemsen, Lars Kaderali, Marco Binder

High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response Journal Article

In: Life Sci. Alliance, vol. 6, no. 10, 2023, ISSN: 2575-1077.

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Apurva A. Govande, Aleksandra W. Babnis, Christian Urban, Matthias Habjan, Rune Hartmann, Philip J. Kranzusch, Andreas Pichlmair

RNase L-activating 2′–5′ oligoadenylates bind ABCF1, ABCF3 and Decr-1 Journal Article

In: vol. 104, no. 9, 2023, ISSN: 1465-2099.

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Quirin Emslander, Karsten Krey, Sabri Hamad, Susanne Maidl, Lila Oubraham, Joshua Hesse, Alexander Henrici, Katharina Austen, Julia Mergner, Vincent Grass, Andreas Pichlmair

MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake Journal Article

In: Viruses, vol. 15, no. 8, 2023, ISSN: 1999-4915.

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Thomas Phelan, Clara Lawler, Andreas Pichlmair, Mark A. Little, Andrew G. Bowie, Gareth Brady

Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO Journal Article

In: J Virol, vol. 97, no. 3, 2023, ISSN: 1098-5514.

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Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H. Christensen, Yonas M. Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I. Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M. Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E. Müller, Manabu Igarashi, Hiroki Kato

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication Journal Article

In: Science, vol. 379, no. 6632, pp. 586–591, 2023, ISSN: 1095-9203.

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Knud Esser, Xiaoming Cheng, Jochen M. Wettengel, Julie Lucifora, Lea Hansen-Palmus, Katharina Austen, Armando A. Roca Suarez, Sarah Heintz, Barbara Testoni, Firat Nebioglu, Minh Tu Pham, Shangqing Yang, Alma Zernecke, Dirk Wohlleber, Marc Ringelhan, Mathias Broxtermann, Daniel Hartmann, Norbert Hüser, Julia Mergner, Andreas Pichlmair, Wolfgang E. Thasler, Mathias Heikenwalder, Georg Gasteiger, Andreas Blutke, Axel Walch, Percy A. Knolle, Ralf Bartenschlager, Ulrike Protzer

Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes Journal Article

In: Cellular and Molecular Gastroenterology and Hepatology, vol. 16, no. 2, pp. 201–221, 2023, ISSN: 2352-345X.

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2022

Laura M. Mateyka, Vincent Grass, Andreas Pichlmair, Dirk H. Busch, Elvira D’Ippolito

SARS-CoV-2 CD8+ T cell killing assays using replicating viruses and transgenic antigens Journal Article

In: STAR Protocols, vol. 3, no. 4, 2022, ISSN: 2666-1667.

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Valter Bergant, Shintaro Yamada, Vincent Grass, Yuta Tsukamoto, Teresa Lavacca, Karsten Krey, Maria‐Teresa Mühlhofer, Sabine Wittmann, Armin Ensser, Alexandra Herrmann, Anja vom Hemdt, Yuriko Tomita, Shutoku Matsuyama, Takatsugu Hirokawa, Yiqi Huang, Antonio Piras, Constanze A Jakwerth, Madlen Oelsner, Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Beate M Kümmerer, Alexey Stukalov, Carsten B Schmidt‐Weber, Manabu Igarashi, Thomas Gramberg, Andreas Pichlmair, Hiroki Kato

Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases Journal Article

In: The EMBO Journal, vol. 41, no. 17, 2022, ISSN: 1460-2075.

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M.I. Hollenhorst, R. Nandigama, S.B. Evers, I. Gamayun, N.A. Wadood, A. Salah, M. Pieper, A. Wyatt, A. Stukalov, A. Gebhardt, W. Nadolni, W. Burow, C. Herr, C. Beisswenger, S. Kusumakshi, F. Ectors, T.I. Kichko, L. Hübner, P. Reeh, A. Munder, S. Wienhold, M. Witzenrath, R. Bals, V. Flockerzi, T. Gudermann, M. Bischoff , P. Lipp, S. Zierler, V. Chubanov, A. Pichlmair, P. König, U. Boehm, G. Krasteva-Christ

Bitter Taste Signaling in Tracheal Epithelial Brush Cells Elicits Innate Immune Responses to Bacterial Infection Journal Article

In: The Journal of Clinical Investigation, vol. 132, no. 13, 2022, ISSN: 1558-8238.

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Hengyuan Liu, Valter Bergant, Goar Frishman, Andreas Ruepp, Andreas Pichlmair, Michelle Vincendeau, Dmitrij Frishman

Influenza A Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity Journal Article

In: Viruses, vol. 14, no. 7, 2022, ISSN: 1999-4915.

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M.C. Serrero, V. Girault, S. Weigang, T.M. Greco, A. Ramos-Nascimento, F. Anderson, A. Piras, A.H. Martinez, J. Hertzog, A. Binz, A. Pohlmann, U. Prank, J. Rehwinkel, R. Bauerfeind, I.M. Cristea, A. Pichlmair, G. Kochs, B. Sodeik

The Interferon-inducible GTPase MxB Promotes Capsid Disassembly and Genome Release of Herpesviruses Journal Article

In: eLife, vol. 11, pp. e76804, 2022, ISSN: 2050-084X.

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S. Ambike, C. Cheng, M. Feuerherd, S. Velkov, D. Baldassi, S.Q. Afridi, D. Porras-Gonzalez, X. Wei, P. Hagen, N. Kneidinger, M.G. Stoleriu, V. Grass, G. Burgstaller, A. Pichlmair, O.M. Merkel, C. Ko, T. Michler

Targeting Genomic SARS-CoV-2 RNA with siRNAs Allows Efficient Inhibition of Viral Replication and Spread Journal Article

In: Nucleic Acids Research, vol. 50, no. 1, pp. 333-349, 2022, ISSN: 0305-1048.

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Q. Emslander, K. Vogele, P. Braun, J. Stender, C. Willy, M. Joppich, J.A. Hammerl, M. Abele, C. Meng, A. Pichlmair, C. Ludwig, J.J. Bugert, F.C. Simmel, G.G. Westmeyer

Cell-free Production of Personalized Therapeutic Phages Targeting Multidrug-resistant Bacteria Journal Article

In: Cell Chemical Biology, 2022, ISSN: 2451-9456.

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G. Jocher, V. Grass, S.K. Tschirner, L. Riepler, S. Breimann, T. Kaya, M. Oelsner, S.M. Hamad, L.I. Hofmann, C.P. Blobel, C.B. Schmidt-Weber, O. Gokce, C.A. Jakwerth, J. Trimpert, J. Kimpel, A. Pichlmair, S.F. Lichtenthaler

ADAM10 and ADAM17 Promote SARS-CoV-2 Cell Entry and Spike Protein-mediated Lung Cell Fusion Journal Article

In: EMBO reports, vol. 23, no. 6, pp. e54305, 2022.

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K.I. Wagner, L.M. Mateyka, S. Jarosch, V. Grass, S. Weber, K. Schober, M. Hammel, T. Burrell, B. Kalali, H. Poppert, H. Beyer, S. Schambeck, S. Holdenrieder, A. Strötges-Achatz, V. Haselmann, M. Neumaier, J. Erber, A. Priller, S. Yazici, H. Roggendorf, M. Odendahl, T. Tonn, A. Dick, K. Witter, H. Mijočević, U. Protzer, P.A. Knolle, A. Pichlmair, C.S. Crowell, M. Gerhard, E. D’Ippolito, D.H. Busch

Recruitment of Highly Cytotoxic CD8+ T Cell Receptors in Mild SARS-CoV-2 Infection Journal Article

In: Cell Reports, vol. 38, no. 2, pp. 110214, 2022, ISSN: 2211-1247.

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2021

G. Griffante, F. Gugliesi, S. Pasquero, V. DellÓste, M. Biolatti, A.J. Salinger, S. Mondal, P.R. Thompson, E. Weerapana, R.J. Lebbink, J.A. Soppe, T. Stamminger, V. Girault, A. Pichlmair, G. Oroszlán, D.M. Coen, M. De Andrea, S. Landolfo

Human Cytomegalovirus-induced Host Protein Citrullination is Crucial for Viral Replication Journal Article

In: Nature Communications, vol. 12, no. 1, pp. 3910, 2021, ISSN: 20411723.

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F.L. Pennemann, A. Mussabekova, C. Urban, A. Stukalov, L.L. Andersen, V. Grass, T.M. Lavacca, C. Holze, L. Oubraham, Y. Benamrouche, E. Girardi, R.E. Boulos, R. Hartmann, G. Superti-Furga, M. Habjan, J. Imler, C. Meignin, A. Pichlmair

Cross-species Analysis of Viral Nucleic Acid Interacting Proteins Identifies TAOKs as Innate Immune Regulators Journal Article

In: Nature Communications, vol. 12, no. 1, pp. 7009, 2021, ISSN: 2041-1723.

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B.T. Laudenbach, K. Krey, Q. Emslander, L.L. Andersen, A. Reim, P. Scaturro, S. Mundigl, C. Dächert, K. Manske, M. Moser, J. Ludwig, D. Wohlleber, A. Kröger, M. Binder, A. Pichlmair

NUDT2 Initiates Viral RNA Degradation by Removal of 5'-phosphates Journal Article

In: Nature Communications, vol. 12, no. 1, pp. 6918, 2021, ISSN: 2041-1723.

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D.S. Fischer, M. Ansari, K.I. Wagner, S. Jarosch, Y. Huang, C.H. Mayr, M. Strunz, N.J. Lang, E. D'Ippolito, M. Hammel, L. Mateyka, S. Weber, L.S. Wolff, K. Witter, I.E. Fernandez, G. Leuschner, K. Milger, M. Frankenberger, L. Nowak, K. Heinig-Menhard, I. Koch, M.G. Stoleriu, A. Hilgendorff, J. Behr, A. Pichlmair, B. Schubert, F.J. Theis, D.H. Busch, H.B. Schiller, K. Schober

Single-cell RNA Sequencing Reveals ex vivo Signatures of SARS-CoV-2-reactive T Cells Through ‘Reverse Phenotyping' Journal Article

In: Nature Communications, vol. 12, no. 1, pp. 4515, 2021, ISSN: 2041-1723.

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A. Holleufer, K.G. Winther, H.H. Gad, X. Ai, Y. Chen, L. Li, Z. Wei, H. Deng, J. Liu, N.A. Frederiksen, B. Simonsen, L.L. Andersen, K. Kleigrewe, L. Dalskov, A. Pichlmair, H. Cai, J. Imler, R. Hartmann

Two cGAS-like Receptors Induce Antiviral Immunity in Drosophila Journal Article

In: Nature, 2021, ISSN: 1476-4687.

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M. Krivega, C.M. Stiefel, S. Karbassi, L.L. Andersen, N.K. Chunduri, N. Donnelly, A. Pichlmair, Z. Storchová

Genotoxic Stress in Constitutive Trisomies Induces Autophagy and the Innate Immune Response via the cGAS-STING Pathway Journal Article

In: Communications Biology, vol. 4, no. 1, pp. 831, 2021, ISSN: 2399-3642.

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A. Stukalov, V. Girault, V. Grass, O. Karayel, V. Bergant, C. Urban, D.A. Haas, Y. Huang, L. Oubraham, A. Wang, M.S. Hamad, A. Piras, F.M. Hansen, M.C. Tanzer, I. Paron, L. Zinzula, T. Enghleitner, M. Reinecke, T.M. Lavacca, R. Ehmann, R. Wölfel, J. Jores, B. Kuster, U. Protzer, R. Rad, J. Ziebuhr, V. Thiel, P. Scaturro, M. Mann, A. Pichlmair

Multilevel Proteomics Reveals Host Perturbations by SARS-CoV-2 and SARS-CoV Journal Article

In: Nature, 2021, ISSN: 0028-0836.

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J. Pei, N.R. Beri, A.J. Zou, P. Hubel, H.K. Dorando, V. Bergant, R.D. Andrews, J. Pan, J.M. Andrews, K.C.F. Sheehan, A. Pichlmair, G.K. Amarasinghe, S.L. Brody, J.E. Payton, D.W. Leung

Nuclear-localized Human Respiratory Syncytial Virus NS1 Protein Modulates Host Gene Transcription Journal Article

In: Cell Reports, vol. 37, no. 2, pp. 109803, 2021, ISSN: 2211-1247.

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M. Manček-Keber, I. Hafner-Bratkovič, D. Lainšček, M. Benčina, T. Govednik, S. Orehek, T. Plaper, V. Jazbec, V. Bergant, V. Grass, A. Pichlmair, R. Jerala

Disruption of Disulfides Within RBD of SARS-CoV-2 Spike Protein Prevents Fusion and Represents a Target for Viral Entry Inhibition by Registered Drugs Journal Article

In: The FASEB Journal, vol. 35, no. 6, pp. e21651, 2021.

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D. Stadler, M. Kächele, A.N. Jones, J. Hess, C. Urban, J. Schneider, Y. Xia, A. Oswald, F. Nebioglu, R. Bester, F. Lasitschka, M. Ringelhan, C. Ko, W. Chou, A. Geerlof, M.A. van de Klundert, J.M. Wettengel, P. Schirmacher, M. Heikenwälder, S. Schreiner, R. Bartenschlager, A. Pichlmair, M. Sattler, K. Unger, U. Protzer

Interferon-induced Degradation of the Persistent Hepatitis B Virus cccDNA Form Depends on ISG20 Journal Article

In: EMBO reports, vol. 22, no. 6, pp. e49568, 2021.

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A.C. Gonzalez-Perez, M. Stempel, E. Wyler, C. Urban, A. Piras, T. Hennig, S. Ganskih, Y. Wei, A. Heim, M. Landthaler, A. Pichlmair, L. Dölken, M. Munschauer, F. Erhard, M.M. Brinkmann, S.M. Horner

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts Journal Article

In: mBio, vol. 12, no. 3, pp. e02683-20, 2021.

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D. Lainšček, T. Fink, V. Forstnerič, I. Hafner-Bratkovič, S. Orehek, Ž. Strmšek, M. Manček-Keber, P. Pečan, H. Esih, Š. Malenšek, J. Aupič, P. Dekleva, T. Plaper, S. Vidmar, L. Kadunc, M. Benčina, N. Omersa, G. Anderluh, F. Pojer, K. Lau, D. Hacker, B.E. Correia, D. Peterhoff, R. Wagner, V. Bergant, A. Herrmann, A. Pichlmair, R. Jerala

A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response Journal Article

In: Vaccines, vol. 9, no. 5, 2021, ISSN: 2076-393X.

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A.B.C. Schuren, I.G.J. Boer, E.M. Bouma, M.L. Van de Weijer, A.I. Costa, P. Hubel, A. Pichlmair, R.J. Lebbink, E.J.H.J. Wiertz

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I Journal Article

In: Molecules, vol. 26, no. 2, 2021, ISSN: 1420-3049.

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K. Krey, A. Babnis, A. Pichlmair

System-based Approaches to Delineate the Antiviral Innate Immune Landscape Journal Article

In: Viruses, vol. 12, no. 10, 2020, ISSN: 19994915.

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C. Urban, H. Welsch, K. Heine, S. Wüst, D.A. Haas, C. Dächert, A. Pandey, A. Pichlmair, M. Binder

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis Journal Article

In: Viruses, vol. 12, no. 6, 2020, ISSN: 1999-4915.

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M. Fabits, V.G. Magalhães, B. Chan, V. Girault, E. Elbasani, E. Rossetti, E. Saeland, M. Messerle, A. Pichlmair, V.J. Lisnić, M.M. Brinkmann

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription Journal Article

In: Microorganisms, vol. 8, no. 6, 2020, ISSN: 2076-2607.

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J.D. Wuerth, M. Habjan, M. Kainulainen, B. Berisha, D. Bertheloot, G. Superti-Furga, A. Pichlmair, F. Weber

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition Journal Article

In: mBio, vol. 11, no. 4, 2020.

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S. Sadegh, J. Matschinske, D.B. Blumenthal, G. Galindez, T. Kacprowski, M. List, R. Nasirigerdeh, M. Oubounyt, A. Pichlmair, T.D. Rose, M. Salgado-Albarrán, J. Späth, A. Stukalov, N.K. Wenke, K. Yuan, J.K. Pauling, J. Baumbach

Exploring the SARS-CoV-2 Virus-host-drug Interactome for Drug Repurposing Journal Article

In: Nature Communications, vol. 11, no. 1, 2020.

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