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InnateLab

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InnateLab

Immunopathology of Virus Infections
Institute of Virology
TUM School of Medicine
Technical University of Munich
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Defining highly functional SARS-CoV-2-specific CD8+ T cells

December 20, 2021 No Comments

A great collaborative work observing how long the SARS-CoV-2-specific CD8+ T cell response is lasting, and used engineered T cells to define highly functional cytotoxic signature.

Read More »

Discovery of a cellular degradation mechanism for viral PPP-RNA

December 8, 2021 No Comments

We identified Nudix hydrolase 2 (NUDT2) as one key player to clear cells from viral triphosphorylated RNA (PPP-RNA).

Read More »

Analysis of evolutionary conserved viral nucleic acid binding proteins

December 6, 2021 No Comments

We used conservation of binding properties over evolution to identify proteins that are relevant for innate immunity.

Read More »

Therapeutic potential of ACE2-IgG4-Fc fusion protein against SARS coronaviruses

December 6, 2021 No Comments

This construct can neutralize all SARS coronaviruses at the picomolar range!

Read More »

Mechanism of transcriptional modulation by NS1 of Respiratory Syncytial Virus (RSV)

December 6, 2021 No Comments

In a joint collaborative battle Daisy Leung pubished a mechanism employed by NS1 of RSV to modulate gene transcription. We identified the critical binding partner of NS1 involved in this process.

Read More »

HCMV infection induces citrullination to evade the antiviral defence

December 6, 2021 No Comments

Our collaborators from the Landolfo Lab discovered that HCMV infection triggers viral and host protein citrullination. We helped to characterize the consequences on IFIT1 antiviral function.

Read More »
Page1 Page2 Page3 Page4 Page5

Defining highly functional SARS-CoV-2-specific CD8+ T cells

December 20, 2021 No Comments

A great collaborative work observing how long the SARS-CoV-2-specific CD8+ T cell response is lasting, and used engineered T cells to define highly functional cytotoxic signature.

Read More »

Discovery of a cellular degradation mechanism for viral PPP-RNA

December 8, 2021 No Comments

We identified Nudix hydrolase 2 (NUDT2) as one key player to clear cells from viral triphosphorylated RNA (PPP-RNA).

Read More »

Analysis of evolutionary conserved viral nucleic acid binding proteins

December 6, 2021 No Comments

We used conservation of binding properties over evolution to identify proteins that are relevant for innate immunity.

Read More »

Therapeutic potential of ACE2-IgG4-Fc fusion protein against SARS coronaviruses

December 6, 2021 No Comments

This construct can neutralize all SARS coronaviruses at the picomolar range!

Read More »

Mechanism of transcriptional modulation by NS1 of Respiratory Syncytial Virus (RSV)

December 6, 2021 No Comments

In a joint collaborative battle Daisy Leung pubished a mechanism employed by NS1 of RSV to modulate gene transcription. We identified the critical binding partner of NS1 involved in this process.

Read More »

HCMV infection induces citrullination to evade the antiviral defence

December 6, 2021 No Comments

Our collaborators from the Landolfo Lab discovered that HCMV infection triggers viral and host protein citrullination. We helped to characterize the consequences on IFIT1 antiviral function.

Read More »
Page1 Page2 Page3 Page4 Page5

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D-81675 Munich, Germany

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Prof. Dr. Andreas Pichlmair

Immunopathology of Virus Infections Laboratory, Institute of Virology, Technical University of Munich
Schneckenburgerstr. 8, D-81675 Munich, Germany

tel: +49 (0) 89 4140 9270
email: andreas.pichlmair@tum.de

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