InnateLab logo

InnateLab

Immunopathology of Virus Infections

About

Microbes (viruses, bacteria etc) and their hosts (complex multicellular organisms) co-exist for millions of years. This co-evolution led to the development of intimate interactions between both parties. Such interactions may be essential for the pathogen to replicate (e.g. recruitment of host factors) or for the host to limit spread of the pathogen (e.g. proteins of the innate immune system). Some pathogenic microorganisms, however, can evade the immune system and accellerate disease. Our group is interested in understanding the interactions between pathogenic viruses and their hosts on molecular and functional levels, focusing on RNA-protein and protein-protein interactions.

Molecular Biology of Innate Immunity and Virus Infections
Virus proteins interact with the host cell receptors on the membrane and signalling proteins in the cytoplasm.

Headlines

TRR353: Death Decisions funded!
TRR353: Death Decisions funded!

New opportunities in cell death research!

Targeting host 2’O-methyltransferases to suppress Influenza virus
Targeting host 2’O-methyltransferases to suppress Influenza virus

Our collaborators from Bonn revealed the importance of host methyltransferase MTr1 for influenza and identified a novel anti-influenza compound - now published in Science!

Excellence initiative CiViA is funded!
Excellence initiative CiViA is funded!

Joining forces with our Danish friends at the Center for Immunology of Viral infections (CiViA)!

New host factors mediating SARS-CoV-2 entry and pathogenesis
New host factors mediating SARS-CoV-2 entry and pathogenesis

New publication from our lab in EMBO Reports! We discovered new host factors mediating SARS-CoV-2 entry and pathogenesis: ADAM17 and ADAM10.

previous arrowprevious arrow
next arrownext arrow
.....proud partner of MS-Core@MRI