The recent outbreaks of the monkeypox virus (MPXV) raised concerns about the impact of poxviruses on public health. In our publication in Nature Communications, we present a comprehensive analysis of the transcriptomic, proteomic and phosphoproteomic changes induced by MPXV infection in primary cells. In addition to identifying virus-perturbed pathways, such as innate immunity and TGF-β signalling, we revealed dynamic phosphorylation of both host and virus proteins and uncovered the role of MPXV H5 phosphorylation in its function. Leveraging our omics data, we predicted and validated several drugs that inhibit MPXV replication. We hope our research will deepen the understanding of MPXV biology and facilitate the development of novel therapeutics against MPXV!

Congratulations to Yiqi, Valter, Vince, Quirin, Sabri, Karsten, Alex, and all the collaborators involved in this study!

Read more here: Multi-omics characterization of the monkeypox virus infection

Text by Yiqi.