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Immunopathology of Virus Infections

New Paper on cellular effects of persistent expression of viral nucleic acids

Congratulations to Christian and Hendrik Welsch (Marco Binder lab). Their work on persistent stimulation of cells got accepted in Viruses.

In this collaborative project, Chris and Hendrik found that long-term delivery of RIG-I ligand leads to cytostasis. Surprisingly, unlike found for other innate immune stimuli (e.g. LPS) persistent activation of the RIG-I pathway does not lead to tolerance. We hypothesize that this system recapitulates the situation in HCV-infected livers, which requires constant re-infection of cells in order to persistently propagate the virus. A beautiful story – which you can read here.

Christian Urban

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