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Immunopathology of Virus Infections

New paper on inflammasome activation by dsRNA published in Science!

Congratulations to our collaboration partners Stefan Bauernfried and Veit Hornung with whom we could identify NLRP1 as dsRNA sensor to activate the inflammasome leading to pyroptosis.

Virus generated dsRNA directly binds to NLRP1 to activate the inflammasome. NLRP1 has a quite restricted expression pattern and therefore this type of inflammasome activation escaped the attention thus far. Through the use of our virus collection, we identified the activation of NLRP1 by the dsRNA producing virus Semliki forest virus. The paper just got online in Science, great stuff.

The article can be found here.

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