ZAP

New role of ZC3HAV1/ZAP in protection against HCMV

The Brinkmann Lab employs a multi-omic approach to identify novel antiviral roles of ZAP in decelerating HCMV infections. We bring in the proteomic component.

Using transcriptomics, proteomics and functional analyses, Ana Cristina Gonzalez-Perez from Melanie Brinkmann’s laboratory (Helmholtz Centre for Infection Research, Braunschweig) illuminated the novel antiviral role of ZAP in decelerating HCMV infections by specifically targeting viral UL4/5 transcripts. To highlight the antiviral effect of ZAP on the proteome level, we (Chris/Andreas) contributed time-resolved mass spectrometry profiling of HCMV-infected HHF-1 cells.

Congratulations to Cristina and all the people involved – fantastic work!

Read the full story in the mBio article: The Zinc Finger Antiviral Portein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destablizes Viral UL4/UL5 Transcripts

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