cGAMP in Flies

New cGAS receptors and signalling identified in flies

We helped our collaborators from the Hartmann and Imler labs find two cGAS-like receptors that regulate antiviral immunity in flies!

Fantastic discovery by the Rune Hartmann (Aarhus) and Jean-Luc Imler (Strassbourg) Laboratories now published in Nature! They have found the two new cGAS-like receptors that generate cyclic dinucleotides. These signalling molecules activate a STING-dependent pathway and contribute to antiviral immunity in flies. Our team (Line/Karin/Andreas) have contributed mass spectrometry experiments that helped to better characterize this novel pathway. 

Great Work! Big Congrats!

Read more in the Nature paper: Two cGAS-like receptors induce antiviral immunity in Drosophila

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