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Immunopathology of Virus Infections
HCMV citrullination longer

HCMV infection induces citrullination to evade the antiviral defence

Our collaborators from the Landolfo Lab discovered that HCMV infection triggers viral and host protein citrullination. We helped to characterize the consequences on IFIT1 antiviral function.

Gloria Griffante and colleagues (Santo Landolfo laboratory, University of Turin, Italy) discovered that HCMV infection induced protein citrullination, a post-translational modification catalyzed by PADs. In particular, the host defense protein IFIT1 was citrullinated by PAD2 and treatment with the enzyme impaired its ability to bind 5’PPP-RNA, thus constituting a novel immune evasion strategy. We contributed with mass-spectrometry and RNA-protein binding assays to characterize IFIT1 citrullination sites and PAD2-dependant modulation of its interaction with RNA.

Congratulations for this great work!

Read more in the Nature paper: Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

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