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Immunopathology of Virus Infections

Mechanism of transcriptional modulation by NS1 of Respiratory Syncytial Virus (RSV)

In a joint collaborative battle Daisy Leung pubished a mechanism employed by NS1 of RSV to modulate gene transcription. We identified the critical binding partner of NS1 involved in this process.

In a joint collaborative battle, Daisy Leung published a mechanism employed by NS1 of Respiratory Syncytial Virus (RSV) to modulate gene transcription: We (Valter/Philipp/Andreas) identified that NS1 binds to the mediator complex, an essential component of inducible gene expression. Jingjing and Daisy could show that NS1 thereby blunts the expression of genes associated with innate immunity.

Congratulations particularly to Jingjing, Nina, Jacqueline and Daisy, well done!

Read more in the Cell Reports paper: Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

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