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Immunopathology of Virus Infections

Defining highly functional SARS-CoV-2-specific CD8+ T cells

A great collaborative work observing how long the SARS-CoV-2-specific CD8+ T cell response is lasting, and used engineered T cells to define highly functional cytotoxic signature.

We are finishing the year with an amazing collaborative work performed with Dirk Busch’s lab! In this study, we uncovered that SARS-CoV-2-specific CD8+ T cells are detectable up to 12 months post-infection. Moreover, by scRNA sequencing, we were able to develop cytotoxic engineered T cells allowing us to define cell signature for highly functional SARS-CoV-2-specific CD8+ T cells.

Congratulation to all the people involved in this great study!

Read more in the Cell Reports paper: Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infection

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