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Immunopathology of Virus Infections
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New host factors mediating SARS-CoV-2 entry and pathogenesis

New publication from our lab in EMBO Reports! We discovered new host factors mediating SARS-CoV-2 entry and pathogenesis: ADAM17 and ADAM10.

This amazing study also reports repurposed ADAM inhibitors exerting antiviral activity against SARS-CoV-2 and its related variants of concern both in vitro and ex vivo. Such knowledge will help to develop new therapies to fight against COVID-19 as ADAM17 and ADAM10 expression correlates with disease severity in patients.

Congratulations to Vincent and Sabri, our collaborators from the Lichtenthaler’s lab and all authors!

Read more here: ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion

Text and illustration by Vincent.

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