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InnateLab

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InnateLab

Immunopathology of Virus Infections
Institute of Virology
TUM School of Medicine
Technical University of Munich
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mRNA therapy as a potential treatment against SARS-CoV-2

In this translational project with ETHRIS and Aarhus University, we demonstrated the potential of IFNλ1 mRNA as an effective treatment of SARS-CoV-2 infection in vivo.

In our publication in EMBO reports, we investigated the effectiveness of LNP-formulated IFNλ1  mRNA (ETH47) in treating SARS-CoV-2 infection. ETH47 successfully induced an ISG response without excessive inflammation and inhibited SARS-CoV-2 replication in our in vitro and in vivo models. These promising results highlighted the possibility of using mRNA therapy in treating virus infections and laid the foundations for the upcoming clinical trials of ETH47.

Congratulations to Yiqi, Vince, and our collaborators from ETHRIS and Aarhus University!

Read more here: Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice

Text by Yiqi.

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Institute of Virology,
Immunopathology of viruses
Translatum (Bau 522), Room 22.1.31
Einsteinstr. 25, 81675 Munich

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Prof. Dr. Andreas Pichlmair
Immunopathology of Virus Infections Laboratory, Institute of Virology, Technical University of Munich
Einsteinstr. 25, D-81675 Munich, Germany
tel: +49 (0) 89 4140 9270, email: andreas.pichlmair@tum.de

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