Protein-Protein Interaction Netwrok of Interferon Stimulated Genes

Antiviral Network of Proteins published in Nature Immunology

Philipp’s work on Interferon Stimulated Genes uncovered many unknown functions of the innate immune system

Congratulations to Philipp Hubel and co-authors – our work on the innate immune network got published in Nature Immunology!

The body’s defense strategies against viral infections are as diverse as the attacks themselves. We conducted a survey to systematically investigate the interactions of interferon-stimulated genes (ISGs), which are at the center of coordinating the antiviral immune response. Through integrating data obtained by affinity purification followed by mass spectrometry (AP/MS), published datasets and functional validation experiments, we found many unknown interactions of ISGs, which sheds light on the overall organization of the innate immune system.

Have a look at the paper: “A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape”

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