NS1 picture

Congratulations to our collaborators Anna Płaszczyca and Ralf Bartenschlager (Heidelberg) as well as Pietro and Andreas!

Their work on NS1 interaction with the Dengue virus NS4A-2K-4B precursor protein was published in Plos Pathogens. This very novel interaction is essential to drive replication of Dengue virus. Clearly, viral precursor proteins have many more functions than previously anticipated – still a lot to discover!

The paper “A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle” can be found here.

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