NCBP3 in vivo

Non-redundant function of the alternative cap complex in antiviral immunity – published in PLOS Pathogens

Congratulations to Anna and Valter for publishing a function role of the alternative CBC! The alternative cap binding complex consisting of NCBP1 and -3 exports mRNA but is redundant under physiological conditions. However, virus infection or challenge with innate immune stimuli revealed a critical function of the alternative CBC in modulation of the innate immune system. This was particularly evident in NCBP3 deficient mice that showed increased susceptibility to influenza A virus infection.

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