Andreas Pichlmair, Johanna Buse, Stephanie Jennings, Otto Haller, Georg Kochs, Peter Staeheli Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice. (Journal Article) J Virol, 78 , pp. 11422–11424, 2004, ISSN: 0022-538X. (Abstract | Links | BibTeX) @article{Pichlmair2004,
title = {Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice.},
author = {Andreas Pichlmair and Johanna Buse and Stephanie Jennings and Otto Haller and Georg Kochs and Peter Staeheli},
doi = {10.1128/JVI.78.20.11422-11424.2004},
issn = {0022-538X},
year = {2004},
date = {2004-01-01},
journal = {J Virol},
volume = {78},
pages = {11422--11424},
abstract = {The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models. |
H Weissenböck, Z Hubálek, J Halouzka, A Pichlmair, A Maderner, K Fragner, J Kolodziejek, G Loupal, S Kölbl, N Nowotny Screening for West Nile virus infections of susceptible animal species in Austria. (Journal Article) Epidemiol Infect, 131 , pp. 1023–1027, 2003, ISSN: 0950-2688. (Abstract | BibTeX) @article{Weissenboeck2003,
title = {Screening for West Nile virus infections of susceptible animal species in Austria.},
author = {H Weissenböck and Z Hubálek and J Halouzka and A Pichlmair and A Maderner and K Fragner and J Kolodziejek and G Loupal and S Kölbl and N Nowotny},
issn = {0950-2688},
year = {2003},
date = {2003-01-01},
journal = {Epidemiol Infect},
volume = {131},
pages = {1023--1027},
abstract = {Avian mortality and encephalomyelitis in equines are considered good indicators for West Nile virus (WNV) activity. We retrospectively tested 385 horse sera for WNV antibodies and looked for WNV nucleic acid and/or WNV antigen in paraffin embedded tissues from 12 horses with aetiologically unresolved encephalomyelitis and 102 free-living birds of different species which had been found dead. With the exception of four horses originating from eastern European countries investigated on the occasion of transit through Austria, all horse sera were negative. Nested RT-PCR of the horse tissues yielded no amplification of WNV-RNA. Also, all bird samples, examined by immunohistochemistry, in situ hybridization and nested RT-PCR were negative for WNV. These results indicate that currently WNV cannot be considered a significant pathogen in Austria.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Avian mortality and encephalomyelitis in equines are considered good indicators for West Nile virus (WNV) activity. We retrospectively tested 385 horse sera for WNV antibodies and looked for WNV nucleic acid and/or WNV antigen in paraffin embedded tissues from 12 horses with aetiologically unresolved encephalomyelitis and 102 free-living birds of different species which had been found dead. With the exception of four horses originating from eastern European countries investigated on the occasion of transit through Austria, all horse sera were negative. Nested RT-PCR of the horse tissues yielded no amplification of WNV-RNA. Also, all bird samples, examined by immunohistochemistry, in situ hybridization and nested RT-PCR were negative for WNV. These results indicate that currently WNV cannot be considered a significant pathogen in Austria. |
