New Paper on anti SARS-CoV-2 drug identification tool based on Interactome data
Immunopathology of Virus Infections
New Paper on function of the Cytomegalovirus tegument protein UL35
Here a link to the manuscript.
New Paper on cellular effects of persistent expression of viral nucleic acids
In this collaborative project, Chris and Hendrik found that long-term delivery of RIG-I ligand leads to cytostasis. Surprisingly, unlike found for other innate immune stimuli (e.g. LPS) persistent activation of the RIG-I pathway does not lead to tolerance. We hypothesize that this system recapitulates the situation in HCV-infected livers, which requires constant re-infection of cells in order to persistently propagate the virus. A beautiful story – which you can read here.
Lab Retreat to the Zugspitze
Previous
Next
Non-redundant function of the alternative cap complex in antiviral immunity – published in PLOS Pathogens
Influence of ER-shaping atlastin proteins on Dengue virus replication published in Nature Microbiology
Have a read here.
New Review published on Zika host interactions
The review, titled “Chasing Intracellular Zika Virus Using Proteomics” can be found here.
Pietro wins MPI-B Junior Research award!
Joined retreat of the Institutes of Virology, Molecular Immunology and Experimental Oncology
Congratulations to our collaborators Anna Płaszczyca and Ralf Bartenschlager (Heidelberg) as well as Pietro and Andreas!
The paper “A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle” can be found here.