Immunopathology of Virus Infections
New publication from our lab in EMBO Reports! We discovered new host factors mediating SARS-CoV-2 entry and pathogenesis: ADAM17 and ADAM10.
A great collaborative work observing how long the SARS-CoV-2-specific CD8+ T cell response is lasting, and used engineered T cells to define highly functional cytotoxic signature.
We identified Nudix hydrolase 2 (NUDT2) as one key player to clear cells from viral triphosphorylated RNA (PPP-RNA).
We used conservation of binding properties over evolution to identify proteins that are relevant for innate immunity.
This construct can neutralize all SARS coronaviruses at the picomolar range!
Prof. Dr. Andreas Pichlmair
Immunopathology of Virus Infections Laboratory, Institute of Virology, Technical University of Munich
Einsteinstr. 25, D-81675 Munich, Germany
tel: +49 (0) 89 4140 9270, email: andreas.pichlmair@tum.de
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