We used conservation of binding properties over evolution to identify proteins that are relevant for innate immunity.

This construct can neutralize all SARS coronaviruses at the picomolar range!

In a joint collaborative battle Daisy Leung pubished a mechanism employed by NS1 of RSV to modulate gene transcription. We identified the critical binding partner of NS1 involved in this process.

Our collaborators from the Landolfo Lab discovered that HCMV infection triggers viral and host protein citrullination. We helped to characterize the consequences on IFIT1 antiviral function.

The Brinkmann Lab employs a multi-omic approach to identify novel antiviral roles of ZAP in decelerating HCMV infections. We bring in the proteomic component.

We helped our collaborators from the Hartmann and Imler labs find two cGAS-like receptors that regulate antiviral immunity in flies!