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Immunopathology of Virus Infections

New Paper on anti SARS-CoV-2 drug identification tool based on Interactome data

Congratulations to our collaborators of the Jan Baumbach lab! In a great effort they managed to generate a tool that uses interactome data to identify suitable drugs that may be active against SARS-CoV-2 – now accepted in Nature Communications. They generated a website that serves as highly suitable interface to browse interactomes and to identify suitable drugs ( Fantastic work – congratulations to the manuscript!

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Lab Retreat to the Zugspitze

Mid February our laboratory went for a fantastic 3-day retreat in which we discussed science and the future of the laboratory. The exposed location on the Zugspitze (highest mountain in Germany) was both inspiring and breathtaking (literally). After three exhausting days of scientific discussions we returned with new ideas, future strategies to fight virus infections and a great new group picture.

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Non-redundant function of the alternative cap complex in antiviral immunity – published in PLOS Pathogens

Congratulations to Anna and Valter for publishing a function role of the alternative CBC!
The alternative cap binding complex consisting of NCBP1 and -3 exports mRNA but is redundant under physiological conditions. However, virus infection or challenge with innate immune stimuli revealed a critical function of the alternative CBC in modulation of the innate immune system. This was particularly evident in NCBP3 deficient mice that showed increased susceptibility to influenza A virus infection.

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