New publication from our lab in EMBO Reports! We discovered new host factors mediating SARS-CoV-2 entry and pathogenesis: ADAM17 and ADAM10.

A great collaborative work observing how long the SARS-CoV-2-specific CD8+ T cell response is lasting, and used engineered T cells to define highly functional cytotoxic signature.

We identified Nudix hydrolase 2 (NUDT2) as one key player to clear cells from viral triphosphorylated RNA (PPP-RNA).

We used conservation of binding properties over evolution to identify proteins that are relevant for innate immunity.

This construct can neutralize all SARS coronaviruses at the picomolar range!

In a joint collaborative battle Daisy Leung pubished a mechanism employed by NS1 of RSV to modulate gene transcription. We identified the critical binding partner of NS1 involved in this process.